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Changsha Organic-Herb Inc

Organic Herb Inc. (OHI) has been dedicated to the research and development of innovative nutraceutical ingredients since 1993. Our commitment to science and quality control has earned OHI recognition within the industry ...

Changsha Organic-Herb Inc
NO.2405,Dushidongjia.Xiongju,Mawangdui North Road,
Changsha, HN 410016
China

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Galanthamine HBr Hydrobromide--Lycoris Radiate Extract

Galanthamine HBr Hydrobromide--Lycoris Radiate Extract
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Product Description

DESCRIPTION:

Our product is extracted from the tuberous plant Shorttube Lycoris (botanical name as Lycoris radiata (L.Herit.) Herb.). It is manufactured as galantamine ( galanthamine ) hydrobromide.It is used in the manufacturing of the medication Nivalin and Reminyl which was approved by FDA, they are a strong (reversible) cholinesterase inhibitor, increasing the susceptibility of the organism to acetylcholine, and treat for mild to moderate dementia of the Alzheimer's type in clinic.

The drug galantamine is much inadequate for patient's consumption around the world, because there is a little valuable galantamine in some plants of Amaryllidaceae family. We have extensively planted the herbs and adopted advanced extract technology, for both enhancing the yield and purifying fine products.

Biological effects:

Galanthamine extract is specific, competitive and reversible acetylcholinesterase inhibitor. It is also an allosteric modulator at nicotinic cholinergic receptor sites potentiating cholinergic nicotinic neurotransmission. Both the acetylcholine and nicotine receptors have been suggested as areas related to cognitive impairment. Initially, Galanthamine extract was used in anesthesiology to antagonize the effects of non-depolarizing muscle relaxants, and since then it was rapidly introduced in other areas of medicine, i.e. neurology, ophthalmology, gastroenterology, intensive care and resuscitation, cardiology, physiotherapy.

Galanthamine extract is a product with broad therapeutic index, allowing "soft" manifestation of its effect with individual dosing depending on the particular case.

Several trials already showed that Galantamine 16 and 24 mg/day significantly benefits the cognitive, functional, and behavioral symptoms of AD as compared with placebo and proved also to be very effective in symptomatic treatment of senile dementia of Alzheimer's type

Galanthamine marketed under the name of Reminyl by Johnson & Johnson's Belgian subsidiary, Janssen Pharmaceutica and Britain's Shire Pharmaceuticals, is licensed for the treatment of mild to moderately severe Alzheimer's disease, and was launched in September 2000 and approved by FDA in Feb.2001.

Now, Galanthamine has received regulatory approval in 29 counties: Argentina, Australia, Canada, Czechia, the European Union (except for The Netherlands), Iceland, Korea, Mexico, Norway, Poland, Singapore, South Africa, Switzerland, Thailand, and the United States.