Resveratrol-Grape Skin Extract

Resveratrol-Grape Skin Extract

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Contact Supplier for pricing
Minimum Order:
1 Kilogram
Supply Availability:
10000 Kilogram per Month
Payment Terms:
Western Union, T/T

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Supplier Details

Changsha Organic Herb Inc.

Free Member  (2009)

[ Changsha, HN, China ]

Business Type:  Manufacturer

Supplier has 4 products

Contact Details

Packaging and Delivery

Packaging:
1kg/bag or 25kg/drum
Delivery Lead Time:
5 days

Product Description

Resveratrol-Grape Skin Extract


Product No.:OHI-000238
CAS No.: 501-36-0
Active Ingredient: Trans-Resveratrol
Specification:50% 98% 99%
Molecular formula: C14H12O3
Molecular weight: 228.24
CAS No.: 501-36-0
Melt Point: 253-257
Solubility: Poor solubility in water, soluble in aether, chloroform, ethanol, acetic acid and acetone.
Appearance: Fine crystal powder
Color:White
Specific Rotation:-77. (c=0.2, EtOH)
Molecular structure:

What is resveratrol:
Resveratrol (trans-3,5,4-trihydroxystilbene), belongs to a class of polyphenolic compounds called stilbenes , found largely in the skins of red grapes and root of Polygonum cuspidatum Sieb. et Zucc ( Japanese knotweed), is a component of Ko-jo-kon, an oriental medicine used to treat diseases of the blood vessels, heart and live.. Resveratrol is a fat-soluble compound that occurs in a trans and a cis configuration (see figure 1). Both cis- and trans-resveratrol also occur as glucosides (bound to a glucose molecule). Resveratrol-3-O-beta-glucoside is also called piceid.

Sources
While present in other plants, such as eucalyptus, spruce, and lily, and in other foods such as mulberries and peanuts, resveratrol's most abundant natural sources are Vitis vinifera, labrusca, and muscadine grapes, Polygonum cuspidatum Sieb.




Cardiovascular Effects
Many studies suggest that consuming alcohol (especially red wine) may reduce the incidence of coronary heart disease (CHD). Several studies have demonstrated that resveratrol is an effective antioxidant. It inhibits lipid peroxidation of low-density lipoprotein (LDL), prevents the cytotoxicity of oxidized LDL, and protects cells against lipid peroxidation. It is thought that because it contains highly hydrophilic and lipophilic properties, it can provide more effective protection than other well-known antioxidants, such as vitamins C and E. On the other hand, it is less effective than the antioxidants quercetin and epicatechin found in red wine. Reduced platelet aggregation has also been demonstrated in studies on resveratrol, further contributing to its prevention of atherosclerosis. To date, most of the research on resveratrol's antioxidant and anti-platelet properties has been done in vitro (in an artificial environment using test-tube or tissue-culture preparations). Further studies in animals and humans are necessary to determine whether resveratrol supplementation makes sense.

Cancer-Related Effects
Resveratrol is being studied to see how it affects the initiation, promotion, and progression of cancer. With regard to tumor initiation, it has been shown to act as an antioxidant by inhibiting free radical formation, and as an anti-mutagen in rat models. Resveratrol appears to decrease tumor promotion activity by inhibiting cyclooxygenase-1 (COX-1), an enzyme that converts arachidonic acid to pro-inflammatory substances that stimulate tumor-cell growth . Studies related to progression have found that resveratrol induced human promyelocytic leukemia cell differentiation and inhibited ribonucleotide reductase, an enzyme needed for DNA synthesis in proliferating cells . One appealing characteristic of resveratrol's anti-cancer potential is its minimal toxicity to blood-forming cells . More studies using both cellular and animal models are needed before any such data would be applicable to human use.

The similarity in structure between resveratrol and diethylstilbestrol (a synthetic estrogen) has prompted investigations into resveratrol's potential as a phytoestrogen (a plant compound that produces estrogen-like effects). However, these properties also stimulate the growth of human breast cancer cells . This finding seems contrary to its other anticancer activities, and is a cause for concern.

The Natural Products Association was cited in an article regarding a new dietary supplement that contains resveratrol, a substance researchers believe may help protect human cells from diseases such as cancer and arthritis.

Direct Antioxidant Activity
In the test tube, resveratrol effectively scavenges (neutralizes) free radicals and other oxidants and inhibits low density lipoprotein (LDL) oxidation . However, there is little evidence that resveratrol is an important antioxidant in vivo . After oral consumption of resveratrol, circulating and intracellular levels of resveratrol in humans are likely to be much lower than that of other important antioxidants, such as vitamin C, vitamin E and glutathione. Moreover, the antioxidant activity of resveratrol metabolites, which comprise most of the circulating resveratrol, may be lower than that of resveratrol.

Inhibition of Vascular Smooth Muscle Cell Proliferation
The proliferation of vascular smooth muscle cells plays an important role in the progression of atherosclerosis . Resveratrol has been found to inhibit the proliferation of vascular smooth muscle cells in culture .

Inhibition

Basic Information

Country:
China
Business Type:
Manufacturer
Year Established:
Total Employees:

About Us

Organic Herb Inc. (OHI) has been dedicated to the research and development of innovative nutraceutical ingredients since 1993. Our commitment to science and quality control has earned OHI recognition within the industry as a trusted supplier of ingredients of the highest quality.

OHI is the Developer, Manufacturer, Exporter and Primary Supplier of the most remarkable alternative and complementary herbal health products and raw material available today. OHI develops and manufactures superior nutraceutical ingredients.

Member History

Year Joined:
2009
Membership Type:
Free Member

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